(DLS-042) A Multifunctional Peptide Improve Wound Healing by Anti-inflammation and Pro-Angiogenesis in Diabetic Rat

Hsiu-Yi Chu, Ph.D – Ph.D Student, Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University; Chun-Ming Shih, Ph.D – Division of Cardiology, Department of Internal Medicine, – Taipei Medical University Hospital,

Introduction: For diabetic patients, wounds have a tendency to delay the healing process and progress more fast. High prevalence of diabetes will develop a chronic non-healing wound in their lifetime, such as a diabetic foot ulcer (DFU). The DFU has complex pathology due to persistent hyperglycemia, such as, oxidative stress, infection, chronic inflammatory response, impaired angiogenesis.

Methods: In this study, a multifunctional peptide (MFP) with abilities of improve endothelial cell proliferation, enhance angiogenesis, anti-oxidation, anti-inflammation, and attenuate M2a macrophage survival, was applied for wound healing treatment of diabetic rats.

Results: Results indicate MFP functional as anti-oxidation, increase endothelial cell proliferation, promote angiogenesis, enhance epidermal keratogenesis, anti-inflammation, and increases promoting reparative M2a macrophages survival in diabetic rats wound healing.

Discussion: In conclusion, MFP is a promising peptide, target multiple causes of impaired healing treatment, giving new hope to the problem of DFU therapy.